The eye is unique in its therapeutic challenges. These considerations may guide selection of therapy. There was no incompatibility among drugs and superdisintegrants used for formulations.
This increased surface area would ultimately influence the transport properties of a drug . The reduction in atenolol clearance follows the general trend that the elimination of renally excreted drugs is decreased with increasing age.
The time between introduction of dosage form, its buoyancy in 0. Chemical structure of Atenolol  Related Essays. Statistically the results of wetting volume between the groups were significant and within the groups were highly significant.
A significant beta-blocking effect of atenolol, as measured by reduction of exercise tachycardia, is apparent within one hour following oral administration of a single dose. At the first sign or symptom of impending cardiac failure, patients should be treated appropriately according to currently recommended guidelines, and the response observed closely.
The spectra of pure drug and superdisintegrants were taken. Evaluation of rapidly disintegrating tablets prepared by a direct compression method. The accurately weight powder blend were taken in the funnel. It represents that wetting volume for tablets depends upon the method of preparation and concentration of superdisintegrants.
At particular time points 1, 2,3,4,6,8,10 and 12h10 ml samples were withdrawn by using syringe filter 0.
Due to the relative leakiness of the membrane, rich blood flow and large surface area, conjunctival uptake of a topically applied drug from the tear fluids is typically an order of magnitude greater than corneal uptake .
As noted above, some subgroups e. The time taken for dosage form to emerge on surface of medium called floating lag time FLT or buoyancy lag time BLT and the total duration of time by which dosage form remain buoyant is called total floating time TFT.
Thyrotoxicosis Beta-adrenergic blockade may mask certain clinical signs e. In asthmatic patients, a dose of atenolol producing a greater effect on resting heart rate than propranolol resulted in much less increase in airway resistance.
The pure drug and its formulations along with their excipients were subjected to IR studies. Lipophilic drugs prefer the transcellular route. This indicates that the drug was compatible with the formulation components.
While taking beta blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic.
Two steps are required:/ Formulation and Evaluation of Atenolol Floating Tablets Using Different Polymers: Guargum, Sodium Alginate, Hpmccps and CarbopolHpmccps and Carbopol withN HCl.
Further 1ml of the above solution was diluted to 10 ml with N HCl and absorbance of the resulting solution was observed at nm. Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol killarney10mile.comarathi, killarney10mile.com*, killarney10mile.comuthu Kumar, killarney10mile.comlan ml N HCl at 75rpm.
The time (minutes) Evaluation of atenolol floating tablets formulations. EVALUATION OF ATENOLOL CORE (AT2) AND PRESS COATED (HE) TABLETS Spectrophotometric estimation of atenolol Atenolol was estimated by UV visible.
Formulation and evaluation of gastro retentive floating drug delivery system of Atenolol Composition of different formulations Formulation No.
Atenolol (mg) HPMC K15M (mg) HPMC KM (mg) NaHCO 3 (mg) Mag. Stearate (mg) Talc adjusted to ml with N HCl. Further 1ml of the above. All the sixteen formulation of prepared floating tablets of Atenolol were subjected to in-vitro release studies these studies were carried out using dissolution apparatus, N Hcl (pH ).
The kinetic values obtained for formulation F12 and F16 were shown in Table 5. Formulation and evaluation of buccoadhesive tablets of Atenolol Prasad B Kadam* 1, Remeth J Dias 1, Kailas K Mali 1, Vijay D Havaldar 1 and Niranjan S Mahajan 1.Download